Cancer genetics: a web-based information resource for non-specialists
July 2008
Introduction
This resource provides a brief overview of the evolving field of cancer genetics, with particular emphasis on common situations encountered in primary care. Links to readily accessible websites and references that provide more in-depth information or help are provided throughout. The links have been selected specifically for accuracy, ease of access and use by a non-specialist audience. The resource aims to be of practical use rather than attempting to be all encompassing. Technical terms referred to in the resource are linked to the definitions given in the glossary.
Genetic risk for cancer in the family will usually present with one or more close relatives affected by cancer. This resource gives a brief outline of how to approach the assessment of a patient seeking advice about risk and early surveillance, and in particular the key features that require intervention. The three possible responses to such an enquiry might be reassurance that the situation is not particularly unusual (given the population risks for that cancer), a referral to secondary care for earlier or additional surveillance, or for those that seem to be at high risk, referral for a genetic assessment. This guide covers the basic principles to apply when assessing the family history and the main features to look out for that might indicate a genetic diagnosis.